N-Acetyl-Neuraminic；Sialic acid；NANA
Item No.： AA0117
Store at： -20℃
CAS No.: 131-48-6
C11H19NO9=309.27
Grade: BR
Content: ≥ 98.0%
Solubility: 50mg/ml, clear colorless
Physicochemical properties: white or off white crystalline powder. Specific rotation -32 ° (c=2, water). Soluble in water, slightly soluble in ethanol, insoluble in ether. Melting point: 184-186 ℃
Purpose: biochemical research. Sialic acid is a carbohydrate widely existing in nature. It is also a basic component of many glycoproteins, glycopeptides and glycolipids. It has a wide range of biological functions, such as the regulation of half-life of blood proteins, the neutralization of a variety of toxins, cell adhesion, immune antigen antibody reaction and the protection of cell lysis. In glycoproteins or glycolipids, the ketone group at position 2 forms a glycosidic bond, which makes it located at the non reducing end of the sugar side chain. Its negative charge or unique chemical structure makes it have various physiological specificity. The enzyme that hydrolyzes and removes terminal n-acetylneuraminidase (neuraminidase) is widely distributed in nature, from viruses to animals. By treating the physiological activity changes of this enzyme, the role of this terminal acidic sugar residue has been clarified. For example, this sugar residue constitutes the binding site of influenza virus on the erythrocyte membrane, and plays a major role in the mutual recognition between plasma glycoproteins and hepatocytes or the recognition mechanism of lymphocytes on the circulation pathway. Although the biosynthetic pathway is somewhat different in animals and bacteria, it passes through N-acetylmannosamine or its 6-phosphate, which is catalyzed by specific pyrophosphatase and reacts with CTP to produce CMP-N-acetylneuraminic acid, which is incorporated into the sugar chain by glycosyl transfer reaction
Storage: -20 ℃
