Ara-C/Cytosine β-D-arabinofuranoside/Cytosine arabinoside
Item No.： PHA0121
Store at： 2～8℃
English Name: Ara-C; Cytosine β- D-arabinofuranoside； Cytosine arabinoside； 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone； Arabinocytidine
Other name: cytosine- β- D-furan arabinoside; 1- β- D-arabinofuranosyl-4-amino-2 (1H) - pyrimidinone; Arabinose cytosine; Cytosine arabinoside; Arabinofuranosyl cytosine; Arabinosyl cytosine
CAS No.: 147-94-4
C9H13N3O5=243.22
Grade: ultra pure grade
Content: ≥ 98.0% (HPLC)
Specific rotation: 156 ~ 161 °
Physicochemical Properties: white or almost white crystalline powder, soluble in water, ethanol, chloroform, partially soluble in methanol, almost insoluble in ether, melting point 186 ~ 188 ℃
Purpose: biochemical research. It can inhibit DNA polymerase, interfere with the incorporation of nucleotides into DNA, inhibit nucleotide reductase, and block the reduction of cytosine nucleotides to deoxycytosine nucleotides, but has no significant effect on the synthesis of RNA and protein. Ara-C inserts DNA and inhibits DNA replication by forming a complex with topoisomerase I, resulting in DNA cleavage. Unable to inhibit RNA synthesis.
Storage: 2 ~ 8 ℃
